社名の由来はAlphaGo（AlphaGo – Wikipedia）とはGoogle DeepMindによって開発されたコンピュータ囲碁プログラムのことで、弊社のAI心電図自動解析プログラムはその開発思想の影響を強く受けて生まれました。
また、Alphaは「α＝最初」という意味と、Xは可能性が未知数という意味をもつことから、弊社は医療業界においてAIを活用した心電図解析の自動化と専用心電計を自社開発した最初の会社であり、将来どれほど巨大な存在に成長するか、未知数であることを意味しています。
| 社名 | AlphaGoX株式会社 |
| 設立 | 2024年3月15日 |
| 所在地 | 〒102-0083 東京都千代田区麴町5丁目3番4号 麹町秋山ビルディング８F |
| TEL | 03-6265-6595 |
| FAX | 03-6265-6592 |
| 資本金 | 66,199,000円 |
| 事業内容 | 1.プログラム医療機器の開発・販売および輸出入 2.医療用電子機器の開発・製造・販売および輸出入 3.医療およびヘルスケア全般のビジネスに関するコンサルタント業務 4.医療及びヘルスケア全般に関する技術・事業の研究開発及び支援 5.医薬品、医療用具、医療機器、医薬部外品、医薬消耗品並びにこれらに関連する用品の販売及び輸出入並びにその仲介 6.医学及び医療に関する資料等の刊行および広報活動 |
| 許可等 | 第二種医療機器製造販売業 （東京都知事 許可番号 13B2X10613） |
| 代表取締役 | 小柴 清史 （株式会社人間と科学の研究所 [ IMSI ] 取締役社長） | 常勤 |
| 楊 一平 （創業者 兼 AI心電図自動解析プログラム開発者） | 常勤 | |
| 取締役 | 朱 欣 （東京科学大学 M&Dデータ科学センター AI技術開発分野 教授） | 非常勤 |
| 中村 啓二郎 （東邦大学 医療センター 大橋病院 循環器内科 講師） | 非常勤 | |
| 朱 兆服 | 非常勤 | |
| 監査役 | 石田 博史 （ＫＳＫＫ有限責任事業組合 理事長） | 常勤 |
| 李 小軍 | 非常勤 | |
| 医療顧問 | 医学博士 杉 薫 （医療法人邦友会 小田原循環器病院 病院長、東邦大学名誉教授） | |
| 税務顧問 | 税理士 小野 弘雅 (小野税務会計事務所 代表税理士） | |
| 人事・労務顧問 | 社会保険労務士 越川 祥伸 （社会保険労務士法人 コシカワ 代表社員） |
1987年 新日本証券株式会社入社
1992年 新日本証券株式会社退社
1992年 ソニー生命保険株式会社入社
2002年 ソニー生命保険株式会社退社
2002年 有限会社エフ・エス・ネット創業
2007年 株式会社エフエスネット設立
2015年 上記2 社清算
2015年 （一社）LOS 相談センター専務理事・事務局長就任
2020年 （一社）LOS 相談センター専務理事・事務局長退任
2020年 株式会社人間と科学の研究所入社
2021年 株式会社人間と科学の研究所代表取締役社長就任
2024年 AlphaGoX 株式会社設立に参画し代表取締役に就任
2007年 株式会社東芝入社
2012年 株式会社東芝退社
2012年 NGR 入社
2015年 NGR 退社
2015年 心電技術研究所入社（技術責任者）
2016年 心電技術研究所退社
2017年 NEC Display 入社
2018年 NEC Display 退社
2019年 ソフトバンク株式会社入社（AI 戦略室）
2024年 ソフトバンク株式会社退社
2024年 AlphaGoX 株式会社を創業し代表取締役に就任
Search Space Method for Accelerating Large Character Set
Character Recognition, TECHNICAL REPORT OF IEICE, Vol.103,
No.659, PRMU2003-231, pp.1-6 (2004.2).
Yiping Yang, Ondrej Velek and Masaki Nakagawa: Accelerating
Large Character Set Recognition using Pivots, Proc. 7th
International Conference on Document Analysis and
Recognition (ICDAR), Edinburgh, Scotland, pp.262-267
(2003.8).
Yiping Yang and Masaki Nakagawa: Improving the Structuring
Search Space Method for Accelerating Large Set Character
Recognition, Proc. 9th International Workshop on Frontiers
in Handwriting Recognition (IWFHR), Tokyo, pp. 251-256
(2004.10)
Junko Tokuno, Yiping Yang, Gleidison Pegoretti da Silva,
Akihito Kitadai and Masaki Nakagawa, Pen-Coordinate
Information Modeling by SCPR-based HMM for On-line Japanese
Handwriting Recognition (Japanese), TECHNICAL REPORT OF
IEICE, PRMU 2005-222, Vol.105, No.615, pp117-122
(2006.2).
Yiping Yang, Bilian Zhu and Masaki Nakagawa: Structuring
Search Space for Accelerating Large Set Character
Recognition, IEICE Trans. Inf&Syst., Vol.E88-D, No.8,
pp.1799-1806, August 2005.
Junko Tokuno, Yiping Yang, Gleidson Pegoretti da Silva,
Akihito Kitadai, Masaki Nakagawa: Modeling of Pen-
Coordinate Information in SCPR-based HMM for On-line
Recognition of Handwritten Japanese Characters, Proc.
IWFHR-10 (10th International Workshop on Frontiers in
Handwriting Recognition), La Baule, France, pp.211-216
(2006.10).
Junko Tokuno, Yiping Yang, Gleidson Pegoretti da Silva,
Akihito Kitadai, Masaki Nakagawa: Pen-Coordinate
Information Modeling by SCPR-based HMM for On-line Japanese
Handwriting Recognition, Proc. 18th ICPR (International
Conference on Pattern Recognition), Vol. 3, pp.348-351
(2006.8).
Yiping Yang and Masaki Nakagawa: Layered Search Spaces for
Accelerating Large Set Character Recognition, Proc. 18th
ICPR (International Conference on Pattern Recognition),
Vol. 2, pp.1006-1009
(2006.8).
Hiroshi Haga, Daisuke Sugimoto, Yiping Yang, Harue Sasaki,
Takuya Asai, Koji Shigemura: Capacitive Touchscreen
Integrated Electrostatic Tactile Display with Localized
Sensation. Journal of the Society for Information Display
27(2) 59-71 2019.2.1
Yiping Yang, Hiroshi Haga, Harue Sasaki, Daisuke Sugimoto,
Takuya Asai, Koji Shigemura: Electronic device with force
sensor and haptic feedback in direction perpendicular to a
direction of press
H. Haga, D. Sugimoto, Y. Yang, K. Shigemura (Tianma Japan,
Japan): Electrostatic Tactile Display Integrated with a
Projected Capacitive Touch Screen. IDW ’17 Best Paper Award
Winners
HAP2/INP4-1
(2017.10)
1980年 東芝メディカル株式会社入社
1981年 株式会社東芝に転籍
2003年 東芝メディカルシステムズ株式会社に変更
2018年 キャノンメディカルシステムズ株式会社に社名変更
2021年 キャノンメディカルシステムズ株式会社退社
2024年 AlphaGoX 株式会社入社
今までに取り組んだ研究分野としては、植込み型除細動器除細動効果の推定システム、心電図を用いた呼吸検出方法、生体信号処理・心臓モデリング及びシミュレーション、センサーネットワークを用いた携帯型イベント心電計、など医療におけるトランスレーショナルリサーチの役割を担っている。
今回弊社に取締役兼最高医学責任者（CMO）として参画。
2002年 中国天津大学生体医工学研究科修了 工学修士
2006年 会津大学大学院コンピュータ理工学研究科修了博士(理工学)
2006年 会津大学 特別研究員
2009年 会津大学 コンピュータ理工学部 准教授
2015年 会津大学 コンピュータ理工学部 上級准教授
2024年3月 AlphaGoX株式会社に取締役として参画
2024年9月 東京医科歯科大学（現 東京科学大学）M&Dデータ科学センター AI技術開発分野 教授
Sun Y, Zhu X, Nakamura K, and Wang S, “Evaluation of lesion characteristics and baseline impedance on high-power short-duration radiofrequency catheter ablation using computer simulation”, Heart and Vessels, vol. 38, 1459-67, 2023. IF: 1.6(2022)
Tang Z, Jiang L, Zhu X, and Huang M, “An Internet of Things-Based Home Telehealth System for Smart Healthcare by Monitoring Sleep and Water Usage: A Preliminary Study”, Electronics, vol. 12, 3652, 2023. IF: 2.9(2022)
Wang J, Liu S, Tsai C, Manousakas I, Zhu X, and Lee T, “Signal Quality Analysis of Single-Arm Electrocardiography”, Sensors, vol.23, 5818, 2023. IF:3.9(2022)
Zhao A, Du X, Yuan S, Shen W, Zhu X(correspondence author), and Wang WW, “Automated Detection of Endometrial Polyps from Hysteroscopic Videos Using Deep Learning”, Diagnostics, vol.13, 1409, 2023. IF: 3.6(2022)
Weng W, Zhu X, Jing L, and Dong M “Attention Mechanism Trained with Small Datasets for Biomedical Image Segmentation”, Electronics, vol. 12, 682, 2023. IF: 2.9(2022)
Kudo S, Chen Z, Zhou X, Izu LT, Chen-Izu Y, Zhu X, Tamura T, Kanaya S, Huang M, “A training pipeline of an arrhythmia classifier for atrial fibrillation detection using Photoplethysmography signal”, Frontiers in Physiology, vol. 14, 1084837, 2023. IF: 4.0(2022)
Chen Z, Yang Z, Wang D, Zhu X, Ono N, Altaf-Ul-Amin MD, Kanaya S, Huang M, “Sleep Staging Framework with Physiologically Harmonized Sub-Networks”, Methods, vol.209, 18-28, 2023. IF: 4.8(2022)
Nakamura K, …., Zhu X. Risk of Mortality Prediction Involving Time-Varying Covariates for Patients with Heart Failure Using Deep Learning, Diagnostics, vol.12, 2947, 2022. IF: 3.992(2021)
Liu S, Yang Z, Pan K, Zhu X, and Chen W, Estimation of Left Ventricular Ejection Fraction Using Cardiovascular Hemodynamic Parameters and Pulse Morphological Characteristics with Machine Learning Algorithms, Nutrients, vol.14, 4051, 2022. IF: 6.706(2021)
Zhou X, Nakamura K, Sahara N, Asami M, Toyoda Y, Enomoto Y, Hara H, Noro M, Sugi K, Masao Moroi, Masato Nakamura, Huang M and Zhu X, Exploring and Identifying Prognostic Phenotypes of Patients with Heart Failure Guided by Explainable Machine Learning, Life, vol. 12, 776, 2022. IF: 3.253(2021)
Liu J, Yan S, Lu N, Yang D, Fan C, Lv H, Wang S, Zhu X, et al. “Automatic segmentation of foveal avascular zone based on adaptive watershed algorithm in retinal optical coherence tomography angiography images”, Journal of Innovative Optical Health Sciences, vol. 15, 2242001, 2022. IF: 2.396(2021)
Zhou X, Zhu X, Nakamura K, Noro M, “Electrocardiogram Quality Assessment with A Generalized Deep Learning Model Assisted by Conditional Generative Adversarial Networks”, Life, vol. 11, 1013, 2021. IF: 3.253(2021)
Sun Y, Nakamura K, Zhu X, “The Effect of Myocardial Fat’s Thickness and Myocardial Impedance on Bipolar Radiofrequency Catheter Ablation Using Computer Simulation”, Advances in Science, Technology and Engineering Systems Journal, vol. 6, 83-89, 2021.
Zhou X, Nakamura K, Sahara N, Takagi T, Toyoda Y, Enomoto Y, Hara H, Noro M, Sugi K, Moroi M, Nakamura M, and Zhu X, “Deep Learning-based Recurrence Prediction of Atrial Fibrillation after Catheter Ablation”, Circulation Journal, vol. 86, 299-308, 2021. IF: 3.350(2021)
Hu Y, Li Q, Shen Y, Fujita T, Zhu X, Inoue R, “Theoretical Investigation of the Mechanism by Which A Gain-of-Function Mutation of TRPM4 Channel Causes Conduction Block”, International Journal of Molecular Sciences, vol. 22, 8513, 2021. IF: 6.208(2021)
Hu Y, Li Q, Kurahara L, Shioi N, Hiraishi K, Fujita T, Zhu X, Inoue R, “An Arrhythmic Mutation E7K Facilitates TRPM4 Channel Activation via Enhanced PIP2 Interaction”, Cells, vol. 10, 583, 2021. IF: 7.666(2021)
Niroshana SMI, Zhu X, Chen W, Nakamura K, “A fused-image-based approach to detect obstructive sleep apnea using a single-lead ECG and a 2D convolutional neural network”, PLoS ONE, vol. 16, e0250618, 2021. (IF: 3.24(2021)
Guo Z, Nemoto D, Zhu X, et al. “A polyp detection algorithm can detect small polyps: An ex vivo reading test compared with endoscopists”, Digestive Endoscopy, vol. 33, 162-9, 2021. IF: 6.337(2021)
Sakai M, Rei Sekine, and Zhu X, “Single-channel ECG suitable for ECG-derived respiration”, Biomedical Physics & Engineering Express, vol. 5, 1-13, 2019.
Guo Z, Zhu X, et al. “Automatic polyp recognition from colonoscopy images based on bag of visual words”, International Journal of Applied Science and Engineering, vol. 16, 65-77, 2019.
Zheng Y, Wei D, Zhu X, et al. “Transmural, Interventricular, Apicobasal and Anteroposterior Action Potential Duration Gradients are All Essential to the Genesis of the Concordant and Realistic T wave: a Whole-heart Model Study”, Journal of Electrocardiology, vol. 49, 569-578, 2016. IF: 1.514(2016)
Noro M, Zhu X(equivalent contribution), et al. “Decreased Defibrillation Thresholds and Minimized Myocardial Damage by Implanting Implantable Cardioverter-defibrillators in the Left Axilla”, Circulation Journal, vol. 80, 878-886, 2016. IF: 3.544(2016)
Noro M, Zhu X(equivalent contribution), et al. “Efficacy and Myocardial Injury with Subcutaneous Implantable Cardioverter Defibrillators -A Computer Simulation Study on the Defibrillation Shock Conduction-”, Circulation Journal, vol. 80, 85-92, 2016. IF: 3.544(2016)
Zheng Y, Wei D, Zhu X, Chen W, Fukuda K, and Shimokawa H, “Ventricular fibrillation mechanisms and cardiac restitutions: an investigation by simulation study on whole-heart model,” Computers in Biology and Medicine, vol. 63, 261-8, 2015. IF: 1.521(2015)
Shen W, Luo Z, Wei D, Xu W, and Zhu X, “Load-prediction scheduling algorithm for computer simulation of electrocardiogram in hybrid environments,” Journal of Systems and Software, vol. 102, 182-191, 2015. IF: 1.424(2015)
Noro M, Zhu X, Ito N, et al. “Evaluation of defibrillation safety with increased number of sensing to reduce shocks for ventricular fibrillation in Japanese ICD patients: The SANKS study,” Journal of Arrhythmia, vol. 31, 94-100, 2015.
Noro M, Zhu X(equivalent contribution), Takagi T, et al. “Left axillary pacemaker generator implantation with a direct puncture of the left axillary vein,” Pacing and Clinical Electrophysiology, vol. 38, 35-41, 2015. IF: 1.440(2015)
Kitamura K, Takeuchi R, Ogai K, Zhu X, Chen W, and Nemoto T, “Development of a novel pulse wave velocity measurement system: Using dual piezoelectric elements,” Medical Engineering & Physics, vol. 36, 927-932, 2014. IF: 1.825(2014)
Noro Mahito, Zhu X, et al. “Examination of effective defibrillation based on an electric internal conduction style with different implanted position of ICD generator at ICD shock”, Heart, vol.45 suppl.3, 202-210, 2013.
Zhu X, Wei D, and Osamu Okazaki, “Computer simulation of clinical electrophysiological study”, Pacing and Clinical Electrophysiology, vol. 35, 718-729, 2012. IF: 1.779(2012)
Weijia Lu, Wei D, Zhu X, and Chen W, “A computer model based on real anatomy for electrophysiology study”, Advances in Engineering Software, 2011, 42(7), pp. 463–476. IF: 1.092(2011)
Zhu X, Chen W, Nemoto T, Kitamura K, and Wei D: “Long-term monitoring of heart rate, respiration rhythm, and body movement during sleep based upon a network,” Telemedicine and e-Health, vol. 16, 244-253, 2010. IF: 1.297(2010)
Shen W, Wei D, Xu W, Zhu X, and Yuan S. “Parallelized computation for computer simulation of electrocardiograms using personal computers with multi-core CPU and general-purpose GPU,” Computer Methods and Programs in Biomedicine, vol. 100, 87-96, 2010. IF:1.238(2010)
Lu W, Yang C, Fang Z, Liu X, Zhu X, and Wei D, “Implementation of a Novel Interpolating Method to Epicardial Potential Mapping for Atrial Fibrillation Study,” Computers in Biology and Medicine, vol. 40, 456-463, 2010. IF: 1.112(2010)
Wei D, Hasegawa S, Takahashi K, Ryzhii E, and Zhu X. “A virtual reality for catheter-based EPS based on whole-heart model”, International Journal of Bioelectromagnetism, vol. 11, 2-6, 2009.
Chen W, Zhu X(equivalent contribution), Tetsu Nemoto, Kei-ichiro Kitamura, and Wei D: “Unconstrained monitoring of long-term heart and breath rates during sleep”, Physiological Measurement, vol. 29, N1-10, 2008. IF: 1.567(2010)
Tsutsumi T, Zhu X, Wakatsuki D, Shimizu N, Wakabayashi K, Takeyama Y, and Wei D, “A simulation of ischemic ST segment depression derived from abnormal local action potentials in left ventricular free wall in reference to experimentally measuring injury current”, International Journal of Bioelectromagnetism, vol. 9, 9-10, 2007.
Zhu X, Wei D, and Okazaki O. “Computer simulation of Electrophysiology Study based on whole-heart models”, International Journal of Bioelectromagnetism, vol. 9, 122-124, 2007.
Zhu X, Chen W, Nemoto T, Kanemitsu Y, Kitamura K, Yamakoshi K, and Wei D: “Real-time Monitoring of Respiration Rhythm and Pulse Rate during Sleep”, IEEE Trans. on BME, vol. 53, 2553-63, 2006. IF: 1.782(2010)
Zhu X, Wei D, Wang H. “Computer Simulations of Intracardiac potential with whole-heart model”, Int. J. Bioinformatics Research and Application, vol. 3, 100-122, 2006.
Chen W, Zhu X, Nemoto T, Kanemitsu Y, Kitamura K and Yamakoshi K. “Unconstrained Detection of Respiration Rhythm and Pulse Rate with One Under-pillow Sensor During Sleeping”, Medical & Biological Engineering & Computing, vol. 43, 306-12, 2005. IF: 1.791(2010)
Ding S, Zhu X, Chen W, and Wei D: “Derivation of Respiratory Signal: From Single–Channel ECGs Based on Source Statistics”, International Journal of Bioelectromagnetism, vol. 6, 2004.
Chen W, Zhu X, Nemoto T, Kobayashi T, and Saito T. “Fetal heart rate monitoring from maternal body surface potentials using independent component analysis”, Animal Science Journal, vol. 75, 471-8, 2004. IF: 0.665(2010)
1999年 東邦大学医学部付属佐倉病院 内科学講座
2001年 東京歯科大学付属市川総合病院（出向）
2003年 東邦大学医学部佐倉病院 内科学講座研究生に復職
2008年 東邦大学医療センター佐倉病院 内科学講座助教
2009年 学位取得（第2560）
2009年 東邦大学医療センター大橋病院 循環器内科助教
2010年 群馬県立心臓血管センター 循環器内科（出向）
2013年 UCLA Cardiac Arrhythmia Center 留学
2015年 東邦大学医療センター大橋病院 循環器内科 助教
2021年 東邦大学医療センター大橋病院 循環器内科 講師
2024年3 月 AlphaGoX 株式会社に取締役として参画
日本内科学会認定医(第34090 号)
医学博士（東邦大学乙第2560 号)
日本循環器学会専門医(第17833 号)
不整脈専門医（第1122 号）
ICD/CRT 研修証 （第11-01715C-3）
臨床心臓電気生理研究会 幹事（2016年～）
臨床心臓電気生理研究会 代表幹事（2024年～）
臨床不整脈研究会 世話人（2016年～）
日本不整脈心電学会 評議会（2020年～）
Nakamura M, Kusano K, Schwartz T, Kayser T, Aonuma K.
Impact of High-Voltage Device Implantation in Elderly
Japanese Patients With Heart Failure as Primary Prevention
– Post Hoc Analysis of HINODE. Circ J. 2024 Jun
25;88(7):1118-1124.
Ishii R, Enomoto Y, Nakamura K, Noro M, Hara H, Sugi K,
Moroi M, Nakamura M.Impact of Preprocedural Frailty Status
in Elderly Transvenous Pacemaker Recipients. Int Heart J.
2023;64(6):1025-1031.
Sun Y, Zhu X, Nakamura K, Wang S.
Evaluation of lesion characteristics and baseline impedance
on high-power short-duration radiofrequency catheter
ablation using computer simulation. Heart Vessels. 2023
Dec;38(12):1459-1467.
Okumura Y, Nagashima K, Watanabe R, Yokoyama K, Kato T,
Fukaya H, Hayashi H, Nakahara S, Shimizu W, Iwasaki YK,
Fujimoto Y, Mukai Y, Ejima K, Otsuka T, Suzuki S, Murakami
M, Kimura M, Harada M, Koyama J, Okamatsu H, Yamane T,
Yamashita S, Tokuda M, Narui R, Takami M, Shoda M, Harada
T, Nakajima I, Fujiu K, Hiroshima K, Tanimoto K, Fujino
T, Nakamura K, Kumagai K, Okada A, Kobayashi H, Hayashi T,
Watari Y, Hatsuno M, Tachibana E, Iso K, Sonoda K, Aizawa
Y, Chikata A, Sakagami S, Inoue M, Minamiguchi H, Makino
N, Satomi K, Yazaki Y, Aoyagi H, Ichikawa M, Haruta H,
Hiro T, Okubo K, Arima K, Tojo T, Kihara H, Miyanaga S,
Fukuda Y, Oiwa K, Fujiishi T, Akabane M, Ishikawa N,
Kusano K, Miyamoto K, Tabuchi H, Shiozawa T, Miyamoto K,
Mase H, Murotani K; REHEALTH AF study.
Registry for Evaluating Healthy Life Expectancy and Long-
Term Outcomes after Catheter Ablation of Atrial
Fibrillation in the Very Elderly (REHEALTH AF) study:
rationale and design of a prospective, multicentre,
observational, comparative study.BMJ Open. 2023 Feb
15;13(2):e068894.
Nakamura K, Zhou X, Sahara N, Toyoda Y, Enomoto Y, Hara H,
Noro M, Sugi K, Huang M, Moroi M, Nakamura M, Zhu X.
Risk of Mortality Prediction Involving Time-Varying
Covariates for Patients with Heart Failure Using Deep
Learning Diagnostics (Basel). 2022 Nov 25;12(12):2947
Sahara N, Nakamura K, Moroi M, Nakamura M. High-Density
Mapping to Identify the Slow Conduction in Left Posterior
Fascicular Ventricular Tachycardia. JACC Clin
Electrophysiol. 2022 Jul;8(7):937-938.
Zhou X, Nakamura K, Sahara N, Asami M, Toyoda Y, Enomoto Y,
Hara H, Noro M, Sugi K, Moroi M, Nakamura M, Huang M, Zhu
X. Exploring and Identifying Prognostic Phenotypes of
Patients with Heart Failure Guided by Explainable Machine
Learning. Life (Basel). 2022 May 24;12(6):776.
Hoang JD, Yamakawa K, Rajendran PS, Chan CA, Yagishita
D, Nakamura K, Lux RL, Vaseghi M.
Proarrhythmic Effects of Sympathetic Activation Are
Mitigated by Vagal Nerve Stimulation in Infarcted Hearts.
ACC Clin Electrophysiol. 2022 Apr;8(4):513-525.
Nagayama D, Fujishiro K, Nakamura K, Watanabe Y,
Yamaguchi T, Suzuki K, Shimizu K, Saiki A, Shirai K.
Cardio-Ankle Vascular Index is Associated with Prevalence
and New-Appearance of Atrial Fibrillation in Japanese
Urban Residents: A Retrospective Cross-Sectional and
Cohort Study. Vasc Health Risk Manag. 2022 Feb 2;18:5-15.
Sahara N, Nakamura K, Toyoda Y, Enomoto Y, Kaoru S,
Nakamura M.Heterogeneous scar with functional block in
ventricular tachycardia circuit: Visualization of
moderate high-density mapping. HeartRhythm Case Rep. 2021
Jul 7;7(10):664-668.
Zhou X, Zhu X, Nakamura K, Noro M. Electrocardiogram
Quality Assessment with a Generalized Deep Learning Model
Assisted by Conditional Generative Adversarial Networks.
Life (Basel). 2021 Sep 26;11(10):1013.
Zhou X, Nakamura K, Sahara N, Takagi T, Toyoda Y, Enomoto
Y, Hara H, Noro M, Sugi K, Moroi M, Nakamura M, Zhu X.
Deep Learning-Based Recurrence Prediction of Atrial
Fibrillation After Catheter Ablation. Circ J. 2022 Jan
25;86(2):299-308.
Enomoto Y, Noro M, Toyoda Y, Ishii R, Asami M, Takagi T,
Sahara N, Hashimoto H, Kujime S, Nakamura K, Hara H,
Moroi M, Sugi K, Nakamura M.Safety and feasibility of
implanting a transvenous implantable cardioverter
defibrillator (TV-ICD) in the left axilla. Pacing Clin
Electrophysiol. 2021 Nov;44(11):1810-1816.
Enomoto Y, Noro M, Toyoda Y, Ishii R, Asami M, Takagi T,
Sahara N, Hashimoto H, Kujime S, Nakamura K, Hara H,
Moroi M, Sugi K, Nakamura M.Safety and feasibility of
implanting a transvenous implantable cardioverter
defibrillator (TV-ICD) in the left axilla. Pacing Clin
Electrophysiol. 2021 Nov;44(11):1810-1816.
Electrophysiol. 2021 Nov;44(11):1810-1816.
Enomoto Y, Hara H, Kitano S, Saito S, Hayama H, Amemiya
K, Yazaki Y, Nakamura K, Iijima R, Sugi K, Moroi M,
Nakamura M.Successful Percutaneous Retrieval of an
Embolized Left Atrial Appendage Closure Device in the
Left Ventricular Outflow Tract. Circ J. 2021 Sep
24;85(10):1893.
Nonoguchi NM, Adachi M, Nogami A, Komatsu Y, Sato T, Ueda
A, Ogawa K, Togashi I, Miwa Y, Hoshida K, Momose Y,
Shinoda Y, Kowase S, Nakamura K, Kaneko S, Soejima
K.Stellate Ganglion Phototherapy Using Low-Level Laser:
A Novel Rescue Therapy for Patients With Refractory
Ventricular Arrhythmias.JACC Clin Electrophysiol. 2021
Oct;7(10):1297-1308.
Takagi T, Nakamura K, Asami M, Toyoda Y, Enomoto Y, Moroi
M, Noro M, Sugi K, Nakamura M.Impact of right atrial
structural remodeling on recurrence after ablation for
atrial fibrillation. J Arrhythm. 2021 May 6;37(3):597-
606.
Nakamura K, Takagi T, Kogame N, Asami M, Toyoda Y, Enomoto
Y, Hara H, Moroi M, Noro M, Sugi K, Nakamura M.Impact of
atrial mitral and tricuspid regurgitation on atrial
fibrillation recurrence after ablation.J Electrocardiol.
2021 May-Jun;66:114-121.
Niroshana SMI, Zhu X, Nakamura K, Chen W.A fused-imagebased
approach to detect obstructive sleep apnea using a
single-lead ECG and a 2D convolutional neural network.
PLoS One. 2021 Apr 26;16(4):e0250618.
Enomoto Y, Nakamura K, Ishii R, Toyoda Y, Asami M, Takagi
T, Hashimoto H, Hara H, Sugi K, Moroi M, Nakamura M.Lesion
size and adjacent tissue damage assessment with high
power and short duration radiofrequency ablation:
comparison to conventional radiofrequency ablation power
setting. Heart Vessels. 2021 Sep;36(9):1438-1444.
Nakamura K, Takagi T, Kogame N, Hashimoto H, Asami M,
Toyoda Y, Enomoto Y, Hara H, Noro M, Sugi K, Moroi M,
Nakamura M.The Association of Cardio-Ankle Vascular Index
(CAVI) with Biatrial Remodeling in Atrial Fibrillation.
J Atheroscler Thromb. 2021 Jun 1;28(6):590-603.
Enomoto Y, Hara H, Makino K, Nakamura K, Sugi K, Moroi
M, Nakamura M. Usefulness of an isoproterenol infusion
to differentiate a left atrial appendage thrombus in a
patient with nonvalvular atrial fibrillation.Pacing Clin
Electrophysiol. 2021 Jan;44(1):192-193.
Takagi T, Nakamura K, Hashimoto H, Asami M, Ishii R,
Enomoto Y, Moroi M, Noro M, Sugi K, Nakamura M. The impact
of sleep apnea on right atrial structural remodeling with
atrial fibrillation.J Cardiol. 2020 Jun;75(6):665-672.
Nakamura K, Hara H, Hashimoto H, Makino K, Asami M, Ishii
R, Enomoto Y, Hashimoto G, Iijima R, Moroi M, Nakamura
M.Endoscopy for Incomplete Endothelialization and Left
Atrial Appendage Occlusion With the Watchman Device.
JACC Cardiovasc Interv. 2020 Feb 10;13(3):391-393.
Kujime S, Hara H, Enomoto Y, Nakamura K, Yoshitama T,
Noro M, Moroi M, Sugi K, Nakamura M. Analysis of Heart
Rate Variability in a Patient with Takotsubo
Cardiomyopathy Syndrome on the Actual Onset Day.
Int Heart J. 2019 Nov 30;60(6):1444-1447.
Zhou X, Zhu X, Nakamura K, Mahito N: Premature
Ventricular Contraction Detection from Ambulatory ECG
Using Recurrent Neural Networks. Annu Int Conf IEEE Eng
Med Biol Soc 2018: 2551-2554. 2018
Enomoto Y, Hashimoto H, Ishii R, Torii S, Nakamura K,
Noro M, Sugi K, Moroi M, Nakamura M: Leadless Pacemaker
and Subcutaneous Implantable Cardioverter Defibrillator
Combination in a Hemodialysis Patient. Circ J 82: 3108-
3109, 2018
Enomoto Y, Hashimoto G, Sahara N, Hashimoto H, Niikura
H, Nakamura K, Iijima R, Hara H, Suzuki M, Noro M, Moroi
M, Sugi K, Nakamura M: Congenital Absence of Left Atrial
Appendage Diagnosed by Multimodality Imaging. Int Heart
J 59: 439-442, 2018.
Irie T, Yamakawa K, Hamon D, Nakamura K, Shivkumar K,
Vaseghi M: Cardiac sympathetic innervation via middle
cervical and stellate ganglia and antiarrhythmic
mechanism of bilateral stellectomy. Am J Physiol Heart
Circ Physiol 312: 392-405. 2017.
Kujime S, Sakurada H, Saito N, Enomoto Y, Ito N, Nakamura
K, Fukamizu S, Tejima T, Yambe Y, Nishizaki M, Noro M,
Hiraoka M, Sugi K: Outcomes of Brugada Syndrome Patients
with Coronary Artery Vasospasm. Intern Med. 56: 129-135,
2017.
Nakamura K, Ajijola OA, Aliotta E, Armour JA, Ardell JL,
Shivkumar K.Pathological effects of chronic myocardial
infarction on peripheral neurons mediating cardiac
neurotransmission.Auton Neurosci. 2016 May;197:34-40.
Noro M, Zhu X, Enomoto Y, Asami M, Ishii R, Toyoda Y,
Sahara N, Takagi T, Narabayasi Y, Hashimoto H, Ito N,
Kujime S, Oikawa Y, Tatsunami H, Sakai T, Nakamura K,
Sakata T, Sugi K: Efficacy and Myocardial Injury With
Subcutaneous Implantable Cardioverter Defibrillators –
Computer Simulation of Defibrillation Shock Conduction.
Circ J 80: 85-92, 2015
Noro M, Zhu X, Takagi T, Sahara N, Narabayashi Y,
Hashimoto H, Ito N, Enomoto
Y, Nakamura K, Kujime S, Sakai T, Sakata T, Sugi K: Left
axillary pacemaker generator implantation with a direct
puncture of the left axillary vein. Pacing Clin
Electrophysiol 38: 35-41, 2015
Noro M, Zhu X, Enomoto Y, Oikawa Y, Tatsunami H, Ishii
R, Toyoda Y, Asami M, Sahara N, Takagi T, Narabayashi Y,
Hashimoto H, Ito N, Kujime S, Sakai T, Nakamura K, Sakata
T, Abe H, Sugi K: Decreased Defibrillation Threshold and
Minimized Myocardial Damage With Left Axilla Implantable
Cardioverter Defibrillator Implantation. Circ J 80: 878-86, 2016
Rajendran PS, Nakamura K, Ajijola OA, Vaseghi M, Armour
JA, Ardell JL, Shivkumar K: Myocardial infarction induces
structural and functional remodelling of the intrinsic
cardiac nervous system. J Physiol 594: 321-341, 2016.
Nishiuchi S, Kaseno K, Naito S, Tsukada N, Sasaki T,
Hayano M, Nakamura K, Sato C, Ikeda E, Miki Y, Nakamura
K, Kumagai K, Kimura T, Oshima S, Tada H: A potential
pitfall of the modified 12 lead electrocardiogram (Mason-
Likar modification) in catheter ablation of idiopathic
ventricular arrhythmias originating from the outflow
tract. Europace 17: 1840-1847, 2015.
Macias C, Nakamura K, Tung R, Boyle NG, Kalyanam S,
Bradfield JS: Importance Of Delayed Enhanced Cardiac MRI
In Idiopathic RVOT-VT: Differentiating Mimics Including
Early Stage ARVC And Cardiac Sarcoidosis. J Atr
Fibrillation 7 : 1097, 2014.
Yagishita D, Chui RW, Yamakawa K, Rajendran PS, Ajijola
OA, Nakamura K, So EL, Mahajan A, Shivkumar K, Vaseghi
M: Sympathetic nerve stimulation, not circulating
norepinephrine, modulates T-peak to T-end interval by
increasing global dispersion of repolarization. Circ
Arrhythm Electrophysiol 8: 174-185, 2015.
Sakamoto T, Kumagai K, Nishiuchi S, Fuke E, Miki Y,
Nakamura K, Kaseno K, Koyama K, Naito S, Inoue H, Oshima
S: Predictors of asymptomatic cerebral infarction
associated with radiofrequency catheter ablation for
atrial fibrillation using an irrigated-tip catheter.
Europace 15: 332-338, 2013
Kumagai K, Sakamoto T, Nakamura K, Hayano M, Yamashita
E, Oshima S: Pre-procedural prediction of termination of
persistent atrial fibrillation by catheter ablation as
an indicator of reverse remodeling of the left atrium.
Circ J 77: 1416-1423, 2013
Kumagai K, Sakamoto T, Nakamura K, Nishiuchi S, Hayano
M, Hayashi T, Sasaki T, Aonuma K, Oshima S: Combined
dominant frequency and complex fractionated atrial
electrogram ablation after circumferential pulmonary
vein isolation of atrial fibrillation. J Cardiovasc
Electrophysiol 24: 975-983, 2013
Nakamura K, Naito S, Kaseno K, Tsukada N, Sasaki T, Hayano
M, Nishiuchi S, Fuke E, Miki Y, Sakamoto T, Nakamura K,
Kumagai K, Kataoka A, Takaoka H, Kobayashi Y, Funabashi
N, Oshima S: Optimal observation time after completion
of circumferential pulmonary vein isolation for atrial
fibrillation to prevent chronic pulmonary vein
reconnections. Int J Cardiol 168: 5300-5310, 2013
Kaseno K, Naito S, Nakamura K, Sakamoto T, Sasaki T,
Tsukada N, Hayano M, Nishiuchi S, Fuke E, Miki Y, Nakamura
K, Yamashita E, Kumagai K, Oshima S, Tada H: Efficacy and
safety of periprocedural dabigatran in patients
undergoing catheter ablation of atrial fibrillation. Circ
J 76: 2337-42, 2012
Noro M, Kujime S, Ito N, Enomoto Y, Nakamura K, Sakai T,
Sakata T, Sugi K: Cost effectiveness of radiofrequency
catheter ablation vs. medical treatment for atrial
fibrillation in Japan. -Cost performance for atrial
fibrillation-. Circ J 75: 1860-1866, 2011
Noike H, Nakamura K, Sugiyama Y, Iizuka T, Shimizu K,
Takahashi M, Hirano K, Suzuki M, Mikamo H, Nakagami T,
Shirai K: Changes in cardio-ankle vascular index in
smoking cessationn. J Atheroscler Thromb 17: 517-25, 2010
Nakamura K, Iizuka T, Takahashi M, Shimizu K, Mikamo H,
Nakagami T, Suzuki M, Hirano K, Sugiyama Y, Tomaru T,
Miyashita Y, Shirai K, Noike H. Association between
cardio-ankle vascular index and serum cystatin C levels
in patients with cardiovascular risk factor. J
Atheroscler Thromb 16: 371-379, 2009.
Nakamura K, Tomaru T, Yamamura S, Miyashita Y, Shirai K,
Noike H. Cadio-ankle vascular index is a candidate
predictor of coronary atherosclerosis. Circ J 72: 598-604, 2008.
Noike H, Satoh S, Kawana H, Hirano K, Sakurai T, Sugiyama
Y, Iizuka T, Takahashi M, Shimizu K, Nakamura K, Ohsawa
H, Kawashima T: Angina pectoris presenting with unusual
form of coronary spasm: a case report. J Cardiol 47: 85-89, 2006
Noike H, Hitsumoto T, Sakurai T, Sugiyama Y, Sato S,
Iizuka T, Takahashi M, Shimizu K, Nakamura K, Ohsawa H:
Relationships between intravascular ultrasonographic
findings and coronary risk factors in patients with
normal coronary angiography. J Cardiol 45: 1-10, 2005
Noike H, Hitsumoto T, Sugiyama Y, Sakurai T, Satoh S,
Iizuka T, Takahashi M, Shimizu K, Nakamura K, Ohsawa H:
Mechanism of exercise-induced ST depression based on
hemodynamics during cardiac catheterization. J Cardiol
45: 193-203, 2005
Hitsumoto T, Iizuka T, Takahashi M, Nakamura K, Shimizu
K, Satoh S, Sugiyama Y, Sakurai T, Noike H, Ohsawa H,
Watanabe H, Shirai K: A relationship between insulin
resistance and reduction in oxidative stress in vivo by
atorvastatin. J Cardiol 44: 233-42, 2004
東邦大学医学部（昭和50年卒）
医療法人邦友会 理事長
小田原循環器病院 病院長
東邦大学名誉教授，医学博士
循環器内科，不整脈
日本循環器学会関東甲信越地方会評議員，日本循環器学会認定循環器専門医，日本循環器学会認定FJCS(Fellow of Japanese Circulation Society)Emeritus Fellow，日本不整脈心電学会名誉会員，日本不整脈心電学会認定不整脈専門医，日本内科学会認定内科医，日本心臓病学会特別正会員FJCC（Fellow of Japanese College of Cardiology)，日本臨床薬理学会専門医制度指導医，日本老年医学会会員，日本職業災害医学会会員，日本脈管学会会員,臨床心臓電気生理研究会顧問，臨床不整脈研究会特別世話人，湘南循環器セミナー世話人，神奈川不整脈研究会常任幹事，西湘循環器カンファランス世話人，城南Bench to Bedside カンファランス顧問，城南Arrhythmia Forum顧問，犬山不整脈カンファランス会員，東京湾岸不整脈画像研究会幹事，城南循環器カンファランス幹事，失神研究会世話人，厚生労働省東京労働局地方労災医員，神保整形外科治験審査委員会副委員長, 駒場東邦中学校・高等学校校医，小田原内科医会幹事